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August 20, 2003
Cash Position Increased and the Total Shareholders Equity Improved

Philadelphia, PA, Wednesday, August 20, 2003: Hemispherx Biopharma, Inc. (AMEX: HEB) announced losses for the three months ended June 30, 2003 of $3,689,000 or $0.11 per share compared to losses of $2,634,000 or $0.08 per share for the same period in 2002. The losses in 2003 include $1,906,000 in non-cash charges relating to the discount to face value of the March 12, 2003 6% Senior Convertible Debenture. Excluding these non-cash charges, the losses for the three months ended June 30, 2003 were $1,783,000 or $0.05 per share. Since December 31, 2002, Total Assets have increased $4,203,000 and Stockholder’s Equity has increased $3.309,000 primarily due to the acquisition of certain assets from Interferon Sciences, Inc.

Pivotal Clinical Trial on Cusp of Completion and New Marketing Team Announced

Research and Development costs were down $391,000 (31%) compared to 2002 primarily due to the Phase III ME/CFS Clinical Trial nearing completion and the related costs are lower than a year ago. A marketing program for expanding sales of the FDA-approved product Alferon N® was also announced.

G&A expenses were $838,000 during the three months ended June 30, 2003. Excluding the expense related to the new Alferon division totaling $196,000, G&A expenses were also 25% lower than experienced in the same period in 2002, primarily due to lower legal and public relations expenses.

About Hemispherx

Hemispherx Biopharma, based in Philadelphia, is a biopharmaceutical company engaged in the manufacture and clinical development of new drug entities for treatment of viral and immune-based chronic disorders. Its flagship products include Alferon and the experimental immunotherapeutics/antivirals Ampligen and Oragens. These novel proteins, approved for a category of STD infection, and experimental nucleic acids are being developed for globally important chronic viral diseases and disorders of the immune system including HPV, HIV, CFS, Hepatitis and SARS. Its platform technology includes large and small agent components for potential treatment of various chronic viral infections. Hemispherx has approximately 350 patents comprising its core intellectual property estate, a fully commercialized product (Alferon N) and GMP certified manufacturing facilities for its novel pharma product. For more information please visit www.hemispherx.net

Hemispherx Biopharma, Inc.,
Dianne Will, Investor Relations
(518) 398-6222, Fax: (518) 398-6369

HEB's Web Site: www.hemispherx.net

Information contained in this news release other than historical information, should be considered forward-looking and is subject to various risk factors and uncertainties. For instance, the strategies and operations of Hemispherx involve risk of competition, changing market conditions, change in laws and regulations affecting these industries and numerous other factors discussed in this release and in the Company's filings with the Securities and Exchange Commission. Any specifically referenced investigational drugs and associated technologies of the company (including AmpligenÒ and Oragensä) are experimental in nature and as such are not designated safe and effective by a regulatory authority for general use and are legally available only through clinical trials with the referenced disorders. The forward-looking statements represent the Company's judgment as of the date of this release. The Company disclaims, however, any intent or obligation to update these forward-looking statements. Clinical trials for other potential indications of the approved biologic AlferonÒ do not imply that the product will ever be specifically approved commercially for these other treatment indications including SARS. The Alferon® asset for overseas sales for a category of STD is currently being acquired by the Company as part of a multi-step purchase contract of inventory, intellectual property, commercial licenses and GMP approved facilities, which house the biological operations.